Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma.

@article{Wang2013InsulinRT,
  title={Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma.},
  author={Yu-Ping Wang and Li-yu Huang and Wei-Ming Sun and Zhuang-Zhuang Zhang and Jia-Zhu Fang and Bao-Feng Wei and Bing-Hao Wu and Ze-guang Han},
  journal={Cancer letters},
  year={2013},
  volume={337 1},
  pages={96-106}
}
Insulin receptor tyrosine kinase substrate (IRTKS) is closely associated with actin remodelling and membrane protrusion, but its role in the pathogenesis of malignant tumours, including hepatocellular carcinoma (HCC), is still unknown. In this study, we showed that IRTKS was frequently upregulated in HCC samples, and its expression level was significantly associated with tumour size. Enforced expression of IRTKS in human HCC cell lines significantly promoted their proliferation and colony… CONTINUE READING

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Ago2 promotes tumor metastasis via upregulating FAK expression in hepatocellular carcinoma

  • N. Cheng, Y. Li, Z. G. Han
  • Hepatology
  • 2012
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