Corpus ID: 24287823

Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine.

  title={Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine.},
  author={Konerirajapuram Natarajan Sulochana and Mohanraj Rajesh and Sivaramakrishna Ramakrishnan},
  journal={Indian journal of biochemistry \& biophysics},
  volume={38 5},
The action of lysine as an antidiabetic agent was examined in human volunteers. Eight patients with type 2 DM were orally supplemented with L-lysine hydrochloride 1 g/day in two doses along with antidiabetic tablets (glyciphage or chlorformine), for a period of two months. Periodically their plasma fasting sugar and insulin receptor tyrosine kinase activity was measured in their monocytes. Eight normal healthy volunteers served as controls for comparison of receptor tyrosine kinase activity… Expand
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Abstract Glycation is the process by which reducing sugars spontaneously (nonenzymatically) bind to proteins and result in production of advanced glycation end-products (AGEs). It is one of the majorExpand
Role of Amino Acids on Prevention of Lens Proteins Nonenzymatic Glycation In Vitro, in Senile, and Diabetic Cataract
Abstract Glycation is the process by which reducing sugars bind to proteins, nonenzymatically. Then, a cascade of glycation reactions begin, which ultimately ends up producing various glycationExpand
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Interestingly, APN inhibited tube formation and migration of HREC and HUVEC which suggested a potent anti angiogenic property of APN, suggesting its potential as therapeutic target in PDR. Expand
Similar Aquaporin9 and MAPK Expression Profiles in the Liver of Types 1 and 2 Diabetes Mellitus.
  • J. Hou, Yuan Li, +6 authors Mei Yang
  • Chemistry, Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2018
The upregulation of AQP9 could be involved in gluconeogenesis and co-regulated by the JNK and p38 MAPK pathway in both Types 1 and 2 diabetes mellitus (DM), and these effects could be reversed by insulin treatment. Expand
Antihyperglycemic Effects of Fermented and Nonfermented Mung Bean Extracts on Alloxan-Induced-Diabetic Mice
Mung bean was reported as a potential antidiabetic agent while fermented food has been proposed as one of the major contributors that can reduce the risk of diabetes in Asian populations. In thisExpand
Safety assessment of l-lysine oral intake: a systematic review
The observed adverse events were mainly subjective symptoms related to the gastrointestinal tract such as nausea, stomachache, and diarrhea, and the provisional no-observed-adverse-effect level obtained based on these gastrointestinal symptoms was 6000 mg/ person/day. Expand