Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.

@article{Yamamoto2011InsulinRS,
  title={Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan.},
  author={Rochele Yamamoto and Marc Tatar},
  journal={Aging cell},
  year={2011},
  volume={10 4},
  pages={729-32}
}
Although extensively studied in Caenorhabditis elegans, no work has yet demonstrated for Drosophila melanogaster whether reduced insulin/IGF signaling (IIS) requires the FOXO transcription factor (foxo) to extend lifespan. Here, we conduct genetic epistasis analysis to determine whether foxo is required for chico mutants (insulin receptor substrate) to reduce age-specific mortality and thus extend lifespan. The mutant chico(1) allele strongly extends lifespan relative to wild-type sibs. A… CONTINUE READING
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