Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.

@article{Schreyer2003InsulinRS,
  title={Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.},
  author={Sylvia Schreyer and Daniela Ledwig and Irini Rakatzi and Ingrid Kloeting and J{\"u}rgen Eckel},
  journal={Endocrinology},
  year={2003},
  volume={144 4},
  pages={1211-8}
}
Insulin receptor substrate (IRS) proteins represent key elements of the insulin-signaling cascade. IRS-4 is the most recently characterized member of the IRS family with an undefined in vivo function. In contrast to IRS-1 and IRS-2, IRS-4 exhibits a limited tissue expression, and IRS-4 protein has not been detected in any mouse or primary human tissue so far. The purpose of the present study was to analyze the expression of IRS-4 in rat muscle and human skeletal muscle cells and assess… CONTINUE READING

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