Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts

@article{Akune2002InsulinRS,
  title={Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts},
  author={Toru Akune and Naoshi Ogata and Kazuto Hoshi and Naoto Kubota and Yasuo Terauchi and Kazuyuki Tobe and Hideko Takagi and Yoshiaki Azuma and Takashi Kadowaki and Kozo Nakamura and Hiroshi Kawaguchi},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={159},
  pages={147 - 156}
}
Insulin receptor substrates (IRS-1 and IRS-2) are essential for intracellular signaling by insulin and insulin-like growth factor-I (IGF-I), anabolic regulators of bone metabolism. Although mice lacking the IRS-2 gene (IRS-2-/- mice) developed normally, they exhibited osteopenia with decreased bone formation and increased bone resorption. Cultured IRS-2-/- osteoblasts showed reduced differentiation and matrix synthesis compared with wild-type osteoblasts. However, they showed increased receptor… CONTINUE READING

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