Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.


Diabetic nephropathy (DN) is a progressive fibrotic condition that may lead to end-stage renal disease and kidney failure. Transforming growth factor-β1 and bone morphogenetic protein-7 (BMP7) have been shown to induce DN-like changes in the kidney and protect the kidney from such changes, respectively. Recent data identified insulin action at the level of… (More)
DOI: 10.1111/febs.12305


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