Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.


Insulin receptor substrate-2 (Irs2) integrates insulin-like signals with glucose and cAMP agonists to regulate beta-cell growth, function, and survival. This study investigated whether increased Irs2 concentration in beta-cells could reduce beta-cell destruction and the incidence of type 1 diabetes in nonobese diabetic (NOD) mice. NOD mice were intercrossed… (More)
DOI: 10.1210/en.2009-0395


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