Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

@article{Parathath2008InsulinRS,
  title={Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.},
  author={Susana R. Parathath and Lori Anne Mainwaring and Africa Fern{\'a}ndez-L and Dane Ohlosson Campbell and Anna Marie Kenney},
  journal={Development},
  year={2008},
  volume={135 19},
  pages={3291-300}
}
Sonic hedgehog (SHH) and insulin-like growth factor (IGF) signaling are essential for development of many tissues and are implicated in medulloblastoma, the most common solid pediatric malignancy. Cerebellar granule neuron precursors (CGNPs), proposed cells-of-origin for specific classes of medulloblastomas, require SHH and IGF signaling for proliferation and survival during development of the cerebellum. We asked whether SHH regulates IGF pathway components in proliferating CGNPs. We report… CONTINUE READING

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