Insulin receptor substrate-1 gene polymorphism and cardiovascular risk in non-insulin dependent diabetes mellitus and patients undergoing coronary angiography.

@article{OsseiGerning1997InsulinRS,
  title={Insulin receptor substrate-1 gene polymorphism and cardiovascular risk in non-insulin dependent diabetes mellitus and patients undergoing coronary angiography.},
  author={Nicholas Ossei-Gerning and Michael W. Mansfield and Max H. Stickland and Peter J. Grant},
  journal={Clinical and laboratory haematology},
  year={1997},
  volume={19 2},
  pages={123-8}
}
Clustering of risk factors for cardiovascular disease related to insulin resistance may account for the increased incidence of vascular disease in these conditions and in non-diabetic subjects. To investigate the relationship between a coding polymorphism in the insulin receptor substrate-1 gene and the presence of cardiovascular risk factors, 209 patients with NIDDM and 452 subjects investigated for coronary artery disease (CAD) were studied. In the NIDDM subjects 22 (10.5%) were heterozygous… CONTINUE READING
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