Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.

@article{Waters1996InsulinRS,
  title={Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave.},
  author={Summer B. Waters and Jeffrey E. Pessin},
  journal={Trends in cell biology},
  year={1996},
  volume={6 1},
  pages={1-4}
}
The insulin receptor is a transmembrane tyrosine kinase that is essential for mediating multiple intracellular signalling cascades that lead ultimately to the biological actions of insulin Tyrosine phosphorylation o f the cytosolic proteins insulin receptor substrate 1 and 2 (IRS1 and IRS2) produces protein 'scaffolding' for the assembly of effector proteins containing Src homology 2 (SH2) domains, thereby generating multisubunit signalling complexes. Although IRS1 was originally isolated as a… CONTINUE READING