Insulin receptor kinase following internalization in isolated rat adipocytes.

@article{Klein1987InsulinRK,
  title={Insulin receptor kinase following internalization in isolated rat adipocytes.},
  author={Hermann H. Klein and Gary R. Freidenberg and Stephan Matth{\"a}i and Jerrold M. Olefsky},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 22},
  pages={
          10557-64
        }
}
We have studied how insulin-mediated internalization of insulin receptors and insulin activation of the insulin receptor kinase might be inter-related. Isolated rat adipocytes were exposed to 0, 6, or 500 ng/ml insulin for 40 min at 37 degrees C. Subsequently, plasma membrane, low-density microsomal membrane and high-density microsomal membrane subcellular fractions were prepared. Measurement of insulin binding to insulin receptors isolated from the membrane fractions revealed that exposure of… CONTINUE READING

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