Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung.

@article{Ruttenstock2010InsulinRI,
  title={Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung.},
  author={Elke Maria Ruttenstock and Toshihiko Doi and Jens Dingemann and P. K. Puri},
  journal={Journal of pediatric surgery},
  year={2010},
  volume={45 5},
  pages={
          948-52
        }
}
PURPOSE The pathogenesis of pulmonary hypoplasia in congenital diaphragmatic hernia (CDH) is still poorly understood. During fetal lung development, the insulin receptor (IR) plays an important role by mediating the cellular uptake of glucose, which is a major substrate for the biosynthesis of surfactant phospholipids. In fetal rat lung, IR gene expression has been revealed on type II pneumocytes. Recent studies have demonstrated that downregulation of pulmonary IR in late gestation causes… CONTINUE READING
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