Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents.

@article{Jonas1996InsulinRI,
  title={Insulin receptor in Aplysia neurons: characterization, molecular cloning, and modulation of ion currents.},
  author={Elizabeth Ann Jonas and Ronald J. Knox and Leonard K Kaczmarek and James H. Schwartz and Diane H. Solomon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1996},
  volume={16 5},
  pages={
          1645-58
        }
}
We have isolated the cDNA for a tyrosine kinase receptor that is expressed in the nervous system of Aplysia californica and that is similar to the vertebrate insulin receptor. Binding studies and immunocytochemical staining show that the receptor is abundant in the bag cell neurons. Application of vertebrate insulin to clusters of bag cell neurons stimulates the phosphorylation of the receptor on tyrosine residues, and exposure of isolated bag cell neurons to insulin produces an increase in… CONTINUE READING

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