Insulin receptor binding kinetics: modeling and simulation studies.

  title={Insulin receptor binding kinetics: modeling and simulation studies.},
  author={Sumanas Wanant and Micheal J Quon},
  journal={Journal of theoretical biology},
  volume={205 3},
Biological actions of insulin regulate glucose metabolism and other essential physiological functions. Binding of insulin to its cell surface receptor initiates signal transduction pathways that mediate cellular responses. Thus, it is of great interest to understand the mechanisms underlying insulin receptor binding kinetics. Interestingly, negative cooperative interactions are observed at high insulin concentrations while positive cooperativity may be present at low insulin concentrations… CONTINUE READING