Insulin receptor and cancer.

  title={Insulin receptor and cancer.},
  author={Antonino Belfiore and Roberta Malaguarnera},
  journal={Endocrine-related cancer},
  volume={18 4},
The widespread epidemic of obesity and type 2 diabetes has raised concern for the impact of these disorders as risk factors for cancer and has renewed the interest for studies regarding the involvement of hyperinsulinemia and insulin receptor (IR) in cancer progression. Overexpression of IR in cancer cells may explain their increased sensitivity to hyperinsulinemia. Moreover, IR isoform A (IR-A) together with autocrine production of its ligand IGF2 is emerging as an important mechanism of… 

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  • A. Belfiore
  • Biology, Medicine
    Current pharmaceutical design
  • 2007
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