Insulin provokes a transient activation of phospholipase C in the rat epididymal fat pad.

@article{Farese1986InsulinPA,
  title={Insulin provokes a transient activation of phospholipase C in the rat epididymal fat pad.},
  author={R V Farese and Joseph Y. Kuo and Jeffery S. Babischkin and John S. Davis},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 19},
  pages={8589-92}
}
Insulin is known to increase the de novo synthesis of inositol phospholipids in rat epididymal fat pads. We presently examined the effects of insulin on the hydrolysis of inositol phospholipids in this tissue. Relatively small (30-40%) but significant increases in inositol phosphates (mono-, di-, and tri-) were apparent within 30-60 s of insulin treatment in fat pads (and adipocytes); thereafter, inositol phosphates returned to control levels. These rapid insulin-induced increases in inositol… CONTINUE READING

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