Insulin production and glucose metabolism in isolated pancreatic islets of rats with NIDDM.

@article{Portha1988InsulinPA,
  title={Insulin production and glucose metabolism in isolated pancreatic islets of rats with NIDDM.},
  author={Bernard Portha and M. H. Giroix and Patricia Serradas and Nils Welsh and Claes Hellerstr{\"o}m and Abdullah Sener and Wiily J Malaisse},
  journal={Diabetes},
  year={1988},
  volume={37 9},
  pages={1226-33}
}
Rats with non-insulin-dependent diabetes mellitus (NIDDM) induced by neonatal injection of streptozocin are known to have a deficient insulin response to glucose. To evaluate to what extent this glucose insensitivity can be attributed to a perturbation of the islet glucose metabolism, we estimated the rates of glucose phosphorylation, glucose utilization, oxygen consumption, and glucose oxidation in islets isolated from normal and NIDDM rats and compared these values with rates of islet insulin… CONTINUE READING
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