Insulin processing by cultured hepatocytes.

  title={Insulin processing by cultured hepatocytes.},
  author={William G. Blackard and R M Smith and Leonard Jarett},
  journal={The American journal of physiology},
  volume={250 2 Pt 1},
The chloroquine-sensitive and chloroquine-insensitive steps in insulin degradation by cultured hepatocytes have been explored by employing low temperature to retard processing. Under standard conditions (90 min association and 60 min dissociation) chloroquine inhibited insulin degradation at 15 degrees C but not at 37 degrees C. However, if the association… CONTINUE READING