Insulin processing and action in adipocytes: evidence for generation of insulin-containing vesicles by leupeptin and monensin.

Abstract

Incubation of adipocytes with 125I-insulin plus leupeptin or monensin, but not chloroquine, resulted in the appearance of a novel peak of 125I-insulin (modal density about 1.20 g/ml) on density gradient centrifugation; the appearance of the peak depended on the presence of specific insulin receptors on the cell surface. The fractions comprising this peak… (More)

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