Insulin modulates the frequency of Ca2+ oscillations in mouse pancreatic islets


Pancreatic islets can adapt to oscillatory glucose to produce synchronous insulin pulses. Can islets adapt to other oscillatory stimuli, specifically insulin? To answer this question, we stimulated islets with pulses of exogenous insulin and measured their Ca2+ oscillations. We observed that sufficiently high insulin (> 500 nM) with an optimal pulse period… (More)
DOI: 10.1371/journal.pone.0183569


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