Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells.

@article{SteelePerkins1990InsulinmimeticAR,
  title={Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells.},
  author={G Steele-Perkins and Richard A. Roth},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 16},
  pages={9458-63}
}
In the present studies, nine different monoclonal antibodies to the extracellular domain of the insulin receptor were tested in three different cell types for their ability to stimulate the intrinsic tyrosine kinase activity of the receptor. Previous studies had suggested that several of these monoclonal antibodies stimulate biological responses without stimulating the intrinsic tyrosine kinase activity of the receptor (Hawley, D. M., Maddux, B. A., Patel, R. G., Wong, K. Y., Manula, P. W… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…