Insulin metabolism in human adipocytes from subcutaneous and visceral depots.

@article{Fawcett2010InsulinMI,
  title={Insulin metabolism in human adipocytes from subcutaneous and visceral depots.},
  author={Janet Fawcett and Hairong Sang and Paska A. Permana and Jennifer L Levy and William C. Duckworth},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={402 4},
  pages={762-6}
}
Subjects with the metabolic syndrome (insulin resistance, glucose intolerance, dyslipidemia, hypertension, etc.) have a relative increase in abdominal fat tissue compared to normal individuals and obesity has also been shown to be associated with a decrease in insulin clearance. The majority of the clearance of insulin is due to the action of insulin-degrading enzyme (IDE) and IDE is present throughout all tissues. Since abdominal fat is increased in obesity we hypothesized that IDE may be… CONTINUE READING