Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone.

@article{Harte2005InsulinmediatedUO,
  title={Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone.},
  author={Alison L. Harte and Phillip G McTernan and Rajkumar Chetty and Simon Ward Coppack and Jonathan Katz and Stephen Smith and Sudhesh Kumar},
  journal={Circulation},
  year={2005},
  volume={111 15},
  pages={1954-61}
}
BACKGROUND Obesity-associated hypertension is likely to be due to multiple mechanisms. Identification of the renin-angiotensin system (RAS) within adipose tissue does, however, suggest a potential causal role for it in obesity-associated hypertension. Obese patients are often hyperinsulinemic, but mechanisms underlying insulin upregulation of the RAS in adipose tissue are unclear. Tumor necrosis factor-alpha (TNF-alpha), an inducer of angiotensinogen in hepatocytes, is elevated in… CONTINUE READING

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