Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns.

@article{Lv2011InsulinmediatedIO,
  title={Insulin-mediated inhibition of p38 mitogen-activated protein kinase protects cardiomyocytes in severe burns.},
  author={Gen-fa Lv and Mao-long Dong and Dahai Hu and Wan-fu Zhang and Yun-chuan Wang and Chao-wu Tang and Xiong-xiang Zhu},
  journal={Journal of burn care & research : official publication of the American Burn Association},
  year={2011},
  volume={32 6},
  pages={591-9}
}
Thermal injury inhibits Akt activation and upregulates p38 mitogen-activated protein kinase, which in turn induces inflammation and increases apoptosis. This study aimed to elucidate the mechanism underlying the cytoprotective role of insulin in severe burns by examining the effects of insulin on inflammation and apoptosis mediated by p38 mitogen-activated protein kinase in burn serum-challenged cardiomyocytes. Neonatal rat cardiomyocytes were exposed to burn serum for 6 hours in the presence… CONTINUE READING
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