Insulin lispro and regular insulin in pregnancy.

@article{Bhattacharyya2001InsulinLA,
  title={Insulin lispro and regular insulin in pregnancy.},
  author={A Bhattacharyya and S. Brown and S M Hughes and Patricia Vice},
  journal={QJM : monthly journal of the Association of Physicians},
  year={2001},
  volume={94 5},
  pages={
          255-60
        }
}
We assessed the safety of insulin lispro in gestational, type 1 and type 2 diabetes mellitus, analysing 635 pregnancies over a period of 7 years. We also evaluated patient satisfaction, sending an internationally-accepted anonymous diabetes treatment satisfaction questionnaire to 22 patients (three type 1, 19 gestational diabetes) who received regular and lispro insulin in successive pregnancies. The success rate of pregnancies in women with gestational diabetes managed with diet alone (n=325… Expand
Use of insulin lispro during pregnancy in women with pregestational diabetes mellitus.
TLDR
Overall, glycaemic control, maternal and foetal outcome were similar to those with human insulin, and the main advantage with respect to human insulin was to importantly reduce maternal severe hypoglycaemia. Expand
A comparison of lispro and regular insulin for the management of type 1 and type 2 diabetes in pregnancy
  • C. Durnwald, M. Landon
  • Medicine
  • The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2008
TLDR
Perinatal outcomes were similar between women treated with both types of insulin and improved glycemic control and lower total insulin requirements during pregnancy compared to those receiving regular insulin. Expand
Insulin lispro therapy in pregnancies complicated by type 1 diabetes: glycemic control and maternal and fetal outcomes.
TLDR
In the experience, insulin lispro therapy during pregnancy in patients with type 1 diabetes resulted in normalization of glycemic control and had no detectable adverse effects on maternal or fetal outcomes. Expand
Progression of retinopathy during pregnancy in type 1 diabetic women treated with insulin lispro.
TLDR
Insulin lispro improves glycemic control during diabetic pregnancy compared with regular insulin with no adverse impact on progression of diabetic retinopathy. Expand
Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience
TLDR
Analysis of data from a multinational, multicenter, retrospective study on mothers with type 1 diabetes mellitus before pregnancy suggests that insulin lispro could be useful for the treatment of hyperglycemia in type 1 diabetic pregnant women. Expand
Pregnancy and Neonatal Outcomes in Gestational Diabetes Treated with Regular Insulin or Fast-Acting Insulin Analogues
TLDR
The data indicate that FAIA achieves similar pregnancy and neonatal outcomes in GDM compared with RI, suggesting patient convenience, FAIA may be better to use during pregnancy. Expand
Is insulin lispro safe in pregnant women: Does it cause any adverse outcomes on infants or mothers?
TLDR
Although HbA1c levels were lower in ILYS group, all outcomes are similar with RHI, so ILYs is an alternative choice in treatment of pregnant women with DM. Expand
Optimizing Insulin Therapy in Pregnant Women with Type 1 Diabetes Mellitus
TLDR
The new short-acting insulin analogs, insulin lispro and insulin aspart, have pharmacodynamic properties which make them ideal for use during pregnancy, and although the number of published studies evaluating the use of insulin l ispro during pregnancy is limited, the majority support its safety. Expand
Insulin therapy in pregnancy complicated by diabetes: are insulin analogs a new tool?
TLDR
Clinical and experimental data on insulin lispro strongly suggest that lis Pro does not have adverse maternal or fetal effects during pregnancy in women with preexisting diabetes, and also that its use in these women results in improved glycemic control, fewer hypoglycemic episodes, and improved patient satisfaction. Expand
A Comparison of the Efficacy of Insulin Aspart and Regular Insulin for Managing Gestational Diabetes and their Effects on Delivery Outcomes
TLDR
Considering insulin dose, frequency of hypoglycemic episodes s well as length of initial hospital stay, insulin aspart was more efficient than regular insulin in controlling blood glucose in patients with GDM. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
Preliminary experience with the use of insulin lispro in pregnant diabetic women.
TLDR
The experience suggests that IL is convenient and practical therapy for women with Type I diabetes in pregnancy, and patients elected to continue with IL after pregnancy. Expand
Metabolic and immunologic effects of insulin lispro in gestational diabetes.
TLDR
Insulin lispro may be considered a treatment option for women with gestational diabetes and verification that it is effective is verified, thereby assuring its safety for use in women with Gestational diabetes. Expand
Meta-Analysis of the Effect of Insulin Lispro on Severe Hypoglycemia in Patients With Type 1 Diabetes
TLDR
It is demonstrated that in type 1 diabetic patients, the frequency of severe hypoglycemia can be reduced by taking insulin lispro as compared with regular human insulin therapy. Expand
Prevention of Perinatal Morbidity by Tight Metabolic Control in Gestational Diabetes Mellitus
TLDR
It is demonstrated that excess mortality and morbidity typically observed in GDM can be prevented by early institution of tight metabolic control, which required insulin in 86% of the authors' patients. Expand
Outcome of diabetic pregnancy and glucose intolerance in pregnancy: an audit of fetal loss in Newcastle General Hospital 1977-1990.
The outcome of pregnancy complicated by established diabetes or gestational glucose intolerance (diabetes mellitus or impaired glucose tolerance) is compared with the outcome of non-diabeticExpand
Outcomes of pregnancy in insulin dependent diabetic women: results of a five year population cohort study
TLDR
Infants of women with established insulin dependent diabetes mellitus have 10 times the population risk of congenital malformations and five times the stillbirth rate and further improvements in the management of pregnancy in diabetic women are needed if target of the St Vincent declaration of 1989 is to be met. Expand
Reduced Frequency of Severe Hypoglycemia and Coma in Well-Controlled IDDM Patients Treated With Insulin Lispro
TLDR
In well-controlled IDDM patients, insulin lispro is associated with a lower risk of severe hypoglycemia and coma, and patients felt that insulin l ispro increased flexibility and freedom of lifestyle. Expand
Maternal postprandial glucose levels and infant birth weight: the Diabetes in Early Pregnancy Study. The National Institute of Child Health and Human Development--Diabetes in Early Pregnancy Study.
TLDR
Monitoring of nonfasting glucose levels rather than the fasting levels, which are more commonly monitored in clinical practice, are necessary to prevent macrosomia. Expand
Maternal postprandial glucose levels and infant birth weight: The Diabetes in Early Pregnancy Study
TLDR
It is concluded that fetal insulin secretion, measured as C-peptide concentration in fetal blood, is not affected by hypoxia from anemia as long as hemoglobin remains within the range 2.1-14.X g/dl. Expand
Can prepregnancy care of diabetic women reduce the risk of abnormal babies?
TLDR
Tight control of the maternal blood glucose concentration in the early weeks of pregnancy can be achieved by the prepregnancy clinic approach and is associated with a highly significant reduction in the risk of serious congenital abnormalities in the offspring. Expand
...
1
2
3
4
...