Insulin lispro: a review of its pharmacological properties and therapeutic use in the management of diabetes mellitus.

@article{Wilde1997InsulinLA,
  title={Insulin lispro: a review of its pharmacological properties and therapeutic use in the management of diabetes mellitus.},
  author={Michelle I. Wilde and Donna McTavish},
  journal={Drugs},
  year={1997},
  volume={54 4},
  pages={
          597-614
        }
}
Insulin lispro, a recombinant insulin analogue, is identical to human insulin except for the transposition of proline and lysine at positions 28 and 29 in the C-terminus of the B chain. The resultant reduced capacity for self-association in solution translates into more rapid absorption of insulin lispro than human regular insulin from subcutaneous sites. Maximum insulin concentrations are higher and are reached earlier with insulin lispro than with human regular insulin, and insulin… CONTINUE READING

Similar Papers

Loading similar papers…