Insulin-like stimulatory effect of human immunoglobulin G on adipocyte lipogenesis.

@article{Khokher1981InsulinlikeSE,
  title={Insulin-like stimulatory effect of human immunoglobulin G on adipocyte lipogenesis.},
  author={M. A. Khokher and Paresh Dandona and S J Janah and G L Coulston},
  journal={Diabetes},
  year={1981},
  volume={30 12},
  pages={1068-71}
}
An investigation into the possible effect of thyroid stimulating immunoglobulin G on lipogenesis by adipocytes led to the discovery that all human IgGs exerted an insulin-like stimulatory effect of lipogenesis by rat adipocytes in vitro. Highly purified polyclonal IgGs prepared from normal subjects had stimulatory potencies similar to those of monoclonal IgGs obtained from patients with IgG myeloma. However, whole sera from myeloma patients with elevated IgG concentrations had a significantly… CONTINUE READING