Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.

@article{Skrtic1997InsulinlikeGF,
  title={Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells.},
  author={Stanko Skrtic and Ville Wallenius and Staffan Ekberg and Allen Brenzel and Axel M. Gressner and J O Jansson},
  journal={Endocrinology},
  year={1997},
  volume={138 11},
  pages={4683-9}
}
Hepatic stellate cells (HSC) are located adjacent to hepatocytes and produce hepatocyte growth factor (HGF) in the normal liver, whereas transformed HSC in fibrotic livers produce transforming growth factor beta1 (TGFbeta1), an inhibitor ofhepatocyte proliferation. In addition to the endocrine actions of hepatic insulin-like growth factor-I (IGF-I), it also stimulates the proliferation of HSC. In this study we found that addition of IGF-1 (20-500 ng/ml) for 48 h to 2- to 7-day-old primary… CONTINUE READING

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