Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells.

@article{lAllemand1996InsulinlikeGF,
  title={Insulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells.},
  author={Dagmar l'Allemand and Armelle Penhoat and M C Lebrethon and R Ard{\`e}vol and Volker von Baehr and Wolfgang Oelkers and Jos{\'e} S{\'a}ez},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1996},
  volume={81 11},
  pages={3892-7}
}
In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation. In the present study, we examined the long term effects of IGF-I and -II on human adult adrenal fasciculata-reticularis cells cultured in a chemically defined medium and compared them to the effects of insulin, human GH, and ACTH. Treatment for 3 days with IGF-I or -II at nanomolar… CONTINUE READING