Insulin-like growth factors and their receptors in growth.

  title={Insulin-like growth factors and their receptors in growth.},
  author={A Joseph D'ercole},
  journal={Endocrinology and metabolism clinics of North America},
  volume={25 3},
The IGFs are essential stimulators of fetal and postnatal growth. Their signals are mediated predominantly by the type I IGF receptor, but another as yet unidentified receptor seems to mediate some actions, especially some of those for IGF-II. During organogenesis, the actions of IGF-I seem to be local (autocrine/paracrine), because it, as well as IGFBPs and IGF receptors, are expressed coordinately in a highly tissue and developmentally specific fashion. IGF-I, however, most likely assumes… CONTINUE READING
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