Insulin-like growth factors and insulin: comparative aspects

  title={Insulin-like growth factors and insulin: comparative aspects},
  author={E. Rudolf Froesch and Juergen Zapf},
IGF I and IGF II are two insulin-like growth factors resembling insulin in many respects. They stem from a common precursor, act through receptors similar to the insulin receptor with which they cross-react. When administered in large amounts they produce hypoglycemia. Their major effects, however, are on replication and differentiation of cells of mesodermal origin. IGF I is the major growth promoting factor in vivo. The synthesis and secretion of IGF I by the liver depend on the growth… CONTINUE READING

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3 Excerpts

Insulin-like growth fac tor I supports differentiation of cultured osteoblast-like cells

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