Insulin-like growth factors and bone: the osteoporosis connection revisited.

  title={Insulin-like growth factors and bone: the osteoporosis connection revisited.},
  author={Clifford J. Rosen and Leah Rea Donahue},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  volume={219 1},
Tremendous advances have been made in knowledge about the pathogenesis and treatment of osteoporosis, a disease that affects more than 25 million Americans. In particular, it has been determined that two major processes are responsible for osteoporotic fractures. These are: 1) bone mass acquisition during adolescence; and 2) bone loss beyond the sixth decade. The former, and possibly the latter, are regulated by genetic and environmental factors. Insulin-like growth factor-I (IGF-I), a… CONTINUE READING

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