Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation.

@article{Kar1997InsulinlikeGF,
  title={Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation.},
  author={Satyabrata Kar and David Hua Seto and Sylvain Dor{\'e} and Uwe K Hanisch and Re´mi Quirion},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 25},
  pages={
          14054-9
        }
}
Insulin-like growth factors-I and -II (IGF-I and -II) are structurally related mitogenic polypeptides with potent growth promoting effects. These peptides and their corresponding IGF-I and -II receptors are selectively localized in the brain. To date, most of the effects of IGFs are believed to be mediated by IGF-I receptors whereas the significance of IGF-II receptor in mediating biological responses remains unclear. In the present study, we characterized the distribution of IGF-I and IGF-II… CONTINUE READING
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