Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions.

@article{Hober1999InsulinlikeGF,
  title={Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions.},
  author={Sophia Hober and J Lundstr{\"o}m Ljung and Mathias Uhl{\'e}n and B. -A. Nilsson},
  journal={FEBS letters},
  year={1999},
  volume={443 3},
  pages={271-6}
}
Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM oxidized glutathione in vitro [Hober, S. et al. (1992) Biochemistry 31, 1749-1756]. In this paper, we show (i) that both IGF-I and IGF-II are unable to form and maintain their native disulfide bonds at redox conditions… CONTINUE READING