Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies.

@article{Roddam2008InsulinlikeGF,
  title={Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies.},
  author={Andrew Wilfred Roddam and Naomi E. Allen and Paul Appleby and Timothy J Key and Luigi Ferrucci and Herbert Ballentine Carter and E. Jeffrey Metter and Chu Chen and Noel S Weiss and Annette Fitzpatrick and Ann W Hsing and James V Lacey and Kathy J. Helzlsouer and Sabina Rinaldi and Elio Riboli and Rudolf Kaaks and Joop A. M. J. L. Janssen and Mark F. Wildhagen and Fritz H. Schroeder and Elizabeth A. Platz and Michael J Pollak and Edward L. Giovannucci and Catherine Schaefer and Charles Patrick Quesenberry and Joseph H. Vogelman and Gianluca Severi and Dallas English and Graham G. Giles and P{\"a}r Stattin and G{\"o}ran Hallmans and Mattias Johansson and June Maylin Chan and Peter H. Gann and Steven E. Oliver and Jeff M. P. Holly and Jenny Donovan and François Meyer and Isabelle Bairati and Pilar Galan},
  journal={Annals of internal medicine},
  year={2008},
  volume={149 7},
  pages={461-71, W83-8}
}
Context Insulin-like growth factors (IGFs) and IGF binding proteins may be associated with some cancers. Contribution This reanalysis of individual patient data from 12 studies of the association between IGFs and IGF binding proteins and prostate cancer suggests that higher levels of serum IGF-I are associated with higher risk for prostate cancer. Caution The 12 studies varied in the types of patients they studied and in how they measured IGFs. Implication High IGF-I levels seem to be a risk… CONTINUE READING

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