Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.

@article{Rowzee2009InsulinlikeGF,
  title={Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.},
  author={Anne M. Rowzee and Dale L. Ludwig and Teresa L Wood},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={3611-9}
}
The insulin receptor (IR) isoforms and the IGF type 1 receptor (IGF-1R) share a high degree of structural homology but differ in ligand binding kinetics and functions. We developed a highly specific quantitative PCR assay to quantify and compare IR-A, IR-B, and IGF-1R expression within an RNA population. We determined receptor expression in primary murine mammary epithelial cells (MECs) during postnatal development. Both IR isoform mRNAs were 3- to 16-fold higher than IGF-1R expression at all… CONTINUE READING

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