Insulin-like growth factor receptors in normal and tumorous adult human adrenocortical glands.

@article{Weber1997InsulinlikeGF,
  title={Insulin-like growth factor receptors in normal and tumorous adult human adrenocortical glands.},
  author={Matthias Max Weber and Christoph Josef Auernhammer and Wieland Kiess and D. Engelhardt},
  journal={European journal of endocrinology},
  year={1997},
  volume={136 3},
  pages={296-303}
}
We have identified and characterized insulin-like growth factor (IGF)-I and IGF-II/mannose-6-phosphate (IGF-II/M6P) receptors in normal adult human adrenocortical tissue. Furthermore, we investigated the IGF-I receptor concentration and binding characteristics in benign and carcinomatous adrenocortical tumors. Membrane preparations of 14 normal adrenocortical glands showed a mean specific 125I-IGF-I binding (SB) of 5.0 +/- 0.5% and a competition by unlabeled ligands which is characteristic of… CONTINUE READING

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