Insulin-like growth factor binding proteins in the human adrenal gland

@article{Ilvesmki1993InsulinlikeGF,
  title={Insulin-like growth factor binding proteins in the human adrenal gland},
  author={Vesa Ilvesm{\"a}ki and Werner F Blum and Raimo Voutilainen},
  journal={Molecular and Cellular Endocrinology},
  year={1993},
  volume={97},
  pages={71-79}
}
Biology of insulin-like growth factor binding protein-4 and its role in cancer (review).
TLDR
The effect of altered expression of IGFBP-4 in vivo in colon and other cancers needs to be explored as locally available IGFs appear to stimulate mitogenesis.
The role of epithelial growth factors and insulin growth factors in the adrenal neoplasms.
TLDR
Recent data on the role of IGF and EGF pathways in adrenal development and tumorigenesis and their potential implication in the treatment of the ACC, a rare malignancy with very poor prognosis are presented.
Insulin-like growth factor system on adrenocortical tumorigenesis
Insulin-like growth factor II (IGF-II) is more potent than IGF-I in stimulating cortisol secretion from cultured bovine adrenocortical cells: interaction with the IGF-I receptor and IGF-binding proteins.
TLDR
It is demonstrated that bovine adult adrenocortical cells provide a useful tissue culture model in which the interactions among locally produced IGFs, IGFBPs, and the IGF-I receptor can be evaluated and IGFBps apparently play a modulatory role in IGF-induced stimulation of adrenal steroidogenesis.
Distribution of IGFBP-rP1 in Normal Human Tissues
TLDR
The immunohistochemistry performed on normal human tissues showed a ubiquitous intense staining of peripheral nerves and a variable degree of positive staining in smooth muscle cells, including those from blood vessel walls, gut, bladder, and prostate.
Developmental expression of and effect of betamethasone on the messenger ribonucleic acid levels for peptide growth factors in the baboon fetal adrenal gland.
TLDR
Very different patterns of mRNA levels for IGF-II, IGF type-1 receptor, IGFBP-2 and bFGF were exhibited in the developing baboon Fetal adrenal gland, which may reflect functionally important differences in their respective cellular localization within the cortex, as well as a divergence in the functional development of the fetal, transitional and definitive zones of the baboon fetal adrenal cortex.
Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors.
TLDR
The results confirm the major role of IGF-II in adrenocortical tumorigenesis and suggest that IGFBP-2 may be a regulator of insulin-like growth factor II proliferative effects in this tumor system.
Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors.
TLDR
expression of IGF-II and its receptor (IGF-IR) in pediatric and adult adrenocortical tumors and the effects of a selective IGF-IR kinase inhibitor (NVP-AEW541) on adrenoc Cortical tumor cells were analyzed, suggesting that IGF- IR inhibitors represent a promising therapy for human adrenocortsical carcinoma.
The IGF system in in-vitro human decidualization.
TLDR
The results suggest that the IGF signalling pathway could play a crucial role in the functions of decidualized endometrial cells.
Role of the insulin-like growth factor system in adrenocortical growth control and carcinogenesis.
TLDR
It is evident that high levels of IGF-II in combination with overexpression of the IGF-I-receptor can provide a significant growth advantage for adrenocortical carcinoma cells and thus contribute to the highly malignant phenotype of this rare type of cancer.
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