Insulin-like growth factor binding proteins modulate Müller cell responses to insulin-like growth factors.

@article{King2004InsulinlikeGF,
  title={Insulin-like growth factor binding proteins modulate M{\"u}ller cell responses to insulin-like growth factors.},
  author={Jeffery L. King and Clyde Guidry},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 8},
  pages={
          2848-55
        }
}
PURPOSE Müller cells are consistently identified in diabetic fibrocontractive ocular tissues and, in response to insulin-like growth factor I, generate tractional forces of the type that cause retinal detachment. Recent studies suggest that diabetes-associated increases in vitreous insulin-like growth factor activity cannot be attributed to simple increases in concentration alone, suggesting that more complex biochemical changes in vitreous growth factor control mechanisms are involved. The… CONTINUE READING

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