Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells

@article{Tomimaru2010InsulinlikeGF,
  title={Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells},
  author={Yoshito Tomimaru and Hidetoshi Eguchi and Hiroshi Wada and Takehiro Noda and Masakatsu Murakami and Sachiko Kobayashi and Sigeru Marubashi and Yutaka Takeda and Masahiro Tanemura and Koji Umeshita and Yuichiro Doki and Miwa Mori and Hiroaki Nagano},
  journal={British Journal of Cancer},
  year={2010},
  volume={102},
  pages={1483 - 1490}
}
Background:A striking efficiency of interferon (IFN)-based anticancer therapy for advanced hepatocellular carcinoma (HCC) has been reported. Because its clinical efficiency greatly depends on each patient's local response, prediction of local response is crucial.Methods:Continuous exposure of IFN-α to parental PLC/PRF/5 cells (PLC-P) and a limiting dilution method resulted in the establishment of IFN-resistant cell clones (PLC-Rs). Microarray analyses of PLC-P and PLC-Rs identified insulin-like… CONTINUE READING

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