Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1.

Abstract

IGFBP-5 is known to be involved in various cell phenomena such as proliferation, differentiation, and apoptosis. However, the exact mechanisms by which IGFBP-5 exerts its functions are unclear. In this study, we demonstrate for the first time that IGFBP-5 is a TNFR1-interacting protein. We found that ectopic expression of IGFBP-5 induced TNFR1 gene… (More)
DOI: 10.1016/j.bbrc.2011.01.064

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Cite this paper

@article{Hwang2011InsulinlikeGF, title={Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1.}, author={Jae Ryoung Hwang and Jae Ho Huh and Yoonna Lee and Sang Il Lee and Seung Bae Rho and Je-Ho Lee}, journal={Biochemical and biophysical research communications}, year={2011}, volume={405 4}, pages={545-51} }