Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion.

@article{Russo2005InsulinlikeGF,
  title={Insulin-like growth factor binding protein-2 binding to extracellular matrix plays a critical role in neuroblastoma cell proliferation, migration, and invasion.},
  author={Vincenzo Carlo Russo and Burkhardt Siegfried Sch{\"u}tt and E Andaloro and Sanie Ymer and Andreas Hoeflich and Michael B. Ranke and Leon A Bach and George Arthur Werther},
  journal={Endocrinology},
  year={2005},
  volume={146 10},
  pages={4445-55}
}
IGF binding proteins (IGFBPs) modulate IGF cellular bioavailability and may directly regulate tumor growth and invasion. We have previously shown that IGFBP-2 binds and localizes IGF-I to the pericellular matrix and have provided some evidence suggesting that the heparin binding domain (HBD) or the arginine-glycine-aspartic acid (RGD) integrin binding motif may be involved in these interactions. However, the precise mechanisms involved remain to be elucidated. We therefore mutated the HBD or… CONTINUE READING

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