Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel

@inproceedings{Uzoh2011InsulinlikeGF,
  title={Insulin-like growth factor-binding protein-2 promotes prostate cancer cell growth via IGF-dependent or -independent mechanisms and reduces the efficacy of docetaxel},
  author={C C Uzoh and J M P Holly and Kalina M Biernacka and Raj A. Persad and Ashwani Bahl and David Gillatt and Claire M. Perks},
  booktitle={British Journal of Cancer},
  year={2011}
}
Background:The development of androgen independence, chemo-, and radioresistance are critical markers of prostate cancer progression and the predominant reasons for its high mortality. Understanding the resistance to therapy could aid the development of more effective treatments.Aim:The aim of this study is to investigate the effects of insulin-like growth factor-binding protein-2 (IGFBP-2) on prostate cancer cell proliferation and its effects on the response to docetaxel.Methods:DU145 and PC3… CONTINUE READING

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