Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice

@article{Eckstein2002InsulinlikeGF,
  title={Insulin-like growth factor-binding protein-2 (IGFBP-2) overexpression negatively regulates bone size and mass, but not density, in the absence and presence of growth hormone/IGF-I excess in transgenic mice},
  author={Felix Eckstein and Tatjana Pavicic and Sabine Nedbal and Corina Schmidt and Ulrich Wehr and Walter Albert Rambeck and Eckhard Wolf and Andreas Hoeflich},
  journal={Anatomy and Embryology},
  year={2002},
  volume={206},
  pages={139-148}
}
Insulin-like growth factor-binding protein-2 (IGFBP-2) has been suggested to be a negative regulator of bone growth and maintenance. The objective of this study was to characterize the effect of elevated IGFBP-2 on the skeletal phenotype of adult transgenic mice, in the absence and presence of growth hormone (GH) excess. 43 male mice were examined at an age of 4 months (7 IGFBP-2 transgenic mice, 12 GH transgenic mice, 10 mice carrying both transgenes, and 14 controls). The bone mineral content… CONTINUE READING
19 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

and lean body mass in ovariectomized rats

  • F Bauss, K Lang, C Dony, L Kling
  • 2001

Similar Papers

Loading similar papers…