Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk.

@article{Vorwerk2005InsulinlikeGF,
  title={Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk.},
  author={Peter Vorwerk and K. Mohnike and Heike Wex and Friedrich-Wilhelm Roehl and Martin Zimmermann and Werner Friedrich Blum and Uwe Mittler},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 5},
  pages={3022-7}
}
Despite remarkable advances in the clinical outcome of most children with acute lymphoblastic leukemia, a substantial number of patients ultimately relapse or suffer from side effects of treatment. In the present study, we investigated components of the IGF system for their predictive value to identify patients with an increased risk of relapse. Serum levels of IGF-I, IGF-II, IGF binding protein (IGFBP)-1, IGFBP-2, and IGFBP-3 were measured in 162 children with acute lymphoblastic leukemia… CONTINUE READING

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