Insulin-like growth factor-binding protein-1 and prostate cancer.

  title={Insulin-like growth factor-binding protein-1 and prostate cancer.},
  author={Lisa B. Signorello and Kerstin E Brismar and R R Bergstrom and S. O. Andersson and Alicja Wolk and Dimitirios Trichopoulos and Hans Olov Adami},
  journal={Journal of the National Cancer Institute},
  volume={91 22},
There is growing and persuasive evidence, both experimental (1–4) and epidemiologic (5–7), that the peptide hormone insulin-like growth factor-I (IGF-I) is a critical factor in the development of prostate cancer. Because of their central role in the regulation of bioavailable IGF-I, the insulin-like growth factor-binding proteins (IGFBPs) have also come under scrutiny as potential mediators of prostate cancer risk (8–12). There is considerable disagreement concerning which, if any, of the… CONTINUE READING


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