Insulin-like growth factor-II expression in developing skeletal muscle of double muscled and normal cattle.

@article{Gerrard1994InsulinlikeGF,
  title={Insulin-like growth factor-II expression in developing skeletal muscle of double muscled and normal cattle.},
  author={Dave Gerrard and Alan L. M. Grant},
  journal={Domestic animal endocrinology},
  year={1994},
  volume={11 4},
  pages={
          339-47
        }
}
Double muscled (DM) cattle possess nearly 40% more muscle fibers than normal muscled (NM) beef or dairy cattle. Previous work showed that serum from DM fetuses stimulated proliferation of L6 myoblasts to a greater extent than serum from NM fetuses. Although the exact role of insulin-like growth factor-II (IGF-II) in the regulation of fetal myogenesis is unknown, it has been shown to serve as a autocrine-acting growth factor during terminal differentiation of myoblasts in mitogen-depleted… CONTINUE READING

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