Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.

@article{Rappolee1992InsulinlikeGF,
  title={Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.},
  author={Dan A Rappolee and Karin S. Sturm and Ole Behrendtsen and Gilbert A. Schultz and Roger A. Pedersen and Zena Werb},
  journal={Genes & development},
  year={1992},
  volume={6 6},
  pages={939-52}
}
We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages. mRNA and protein for IGF-II were expressed in preimplantation mouse embryos, but the related factors IGF-I and insulin were not. IGF-I and insulin receptors and the IGF-II/mannose-6-phosphate receptor were expressed. Exogenous IGF-II or IGF-I increased the cell number in cultured blastocysts, but… CONTINUE READING
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