Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.

@article{elBadry1990InsulinlikeGF,
  title={Insulin-like growth factor II acts as an autocrine growth and motility factor in human rhabdomyosarcoma tumors.},
  author={O M el-Badry and Caterina P Minniti and Elise C. Kohn and Peter James Houghton and William H. Daughaday and Lee J. Helman},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1990},
  volume={1 7},
  pages={
          325-31
        }
}
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and appears to arise from developing striated muscle-forming cells. Since insulin-like growth factor II (IGF-II) is involved in normal muscle growth and maturation and elevated IGF-II mRNA levels have previously been reported in rhabdomyosarcomas, we have been studying the possible role of IGF-II in the unregulated growth and invasive potential of these embryonal tumors. In this study, we demonstrate that 13 of 14… CONTINUE READING
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