Insulin-like growth factor-I treatment in two children with growth hormone gene deletions.

@article{Arnhold1999InsulinlikeGF,
  title={Insulin-like growth factor-I treatment in two children with growth hormone gene deletions.},
  author={Ivo Jorge Prado Arnhold and Silviana Braz de Oliveira and Maria Geralda Farah Os{\'o}rio and Berenice B Mendonca},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  year={1999},
  volume={12 4},
  pages={499-506}
}
Two unrelated Brazilian patients had homozygous 6.7 kb deletions in the GH-1 gene (girl and boy, 1.8 and 3.3 yr, heights -7.9 and -6.0 SDS, respectively). Desensitization using small amounts of exogenous GH (0.033 IU/kg body weight/week, divided into daily s.c. injections) was attempted, but anti-GH antibodies appeared. Replacement with usual doses of hGH induced only transient increase in growth. IGF-I therapy with increasing doses resulted in catch-up growth without side-effects. Growth… CONTINUE READING

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